Silica-modified magnetic beads are uniform, superparamagnetic beads coated with silica. The beads can be further modified to carry different functional groups for other applications or used for nucleic acid isolation and purification. Silica-modified magentic beads bind nucleic acids in the presence of chaotrophic salts and alcohol, similar to silica membranes. Our magnetic beads come suspended in sterile water at a concentration of 50 mg/ml.
Carboxy-terminated magnetic beads are uniform, silica-based superparamagnetic beads coated with high density carboxyl functional groups on the surface. The beads are used to bind to nucleic acids in the presence of polyethylene glycol and sodium chloride, which is covered by US Patent 5898071 (DNA Purification using Magnetic Particles).
Other applications include covalent conjugation of primary amine containing ligands via stable amide bonds. Carboxy-terminated magnetic beads are most suitable for conjugation of large proteins.