Carboxy-terminated magnetic beads are uniform, silica-based superparamagnetic beads
Coated with high density carboxyl functional groups on the surface
Nucleic acid binding is mediated in the presence of polyethylene glycol and sodium chloride
Covered by US Patent 5898071 (DNA Purification using Magnetic Particles).
Other applications include covalent conjugation of primary amine containing ligands via stable amide bonds.
Carboxy-terminated magnetic beads are most suitable for conjugation of large proteins.